Eugenol-rich Fraction of Syzygium aromaticum (Clove) Reverses Biochemical and Histopathological Changes in Liver Cirrhosis and Inhibits Hepatic Cell Proliferation
Identifieur interne : 000A95 ( Main/Exploration ); précédent : 000A94; suivant : 000A96Eugenol-rich Fraction of Syzygium aromaticum (Clove) Reverses Biochemical and Histopathological Changes in Liver Cirrhosis and Inhibits Hepatic Cell Proliferation
Auteurs : Shakir Ali [Inde] ; Ram Prasad [Inde] ; Amena Mahmood [Inde] ; Indusmita Routray [Inde] ; Tijjani Salihu Shinkafi [Inde] ; Kazim Sahin [Turquie] ; Omer Kucuk [États-Unis]Source :
- Journal of Cancer Prevention [ 2288-3649 ] ; 2014.
Abstract
Dried flower bud of
Cirrhosis of the liver, which predisposes to hepatocellular carcinoma, was induced by administering thioacetamide (0.03%) in drinking water for 16 weeks. Cirrhotic animals were divided into two groups; the treated group was administered ERF for 9 weeks, one week after discontinuation of thioacetamide, while the other group received normal saline for a similar duration of time.
The treatment with ERF, as determined by histopathology and through a battery of biochemical markers of hepatic injury, oxidative stress and drug metabolizing enzymes, significantly ameliorated the signs of liver cirrhosis. It lowered the elevated levels of alkaline phosphatase, γ-glutamyl transferase and other biochemical changes in liver cirrhosis. Histopathology of the liver corroborated the effect of ERF with biochemical findings. ERF treatment further inhibited cell proliferation, as demonstrated by reduced [3H]-thymidine uptake.
Data provide evidence supporting the protective action of ERF on liver cirrhosis. The study assumes significance because cirrhosis predisposes the liver to cancer, which is characterized by abnormal cell proliferation. ERF in this study is reported to inhibit hepatic cell proliferation and at the same time decrease oxidative stress, which might be the mechanism of protection against liver cirrhosis.
Url:
DOI: 10.15430/JCP.2014.19.4.288
PubMed: 25574464
PubMed Central: 4285960
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001008
- to stream Pmc, to step Curation: 001007
- to stream Pmc, to step Checkpoint: 000833
- to stream Ncbi, to step Merge: 001976
- to stream Ncbi, to step Curation: 001976
- to stream Ncbi, to step Checkpoint: 001976
- to stream Main, to step Merge: 000A97
- to stream Main, to step Curation: 000A95
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Eugenol-rich Fraction of <italic>Syzygium aromaticum</italic> (Clove) Reverses Biochemical and Histopathological Changes in Liver Cirrhosis and Inhibits Hepatic Cell Proliferation</title><author><name sortKey="Ali, Shakir" sort="Ali, Shakir" uniqKey="Ali S" first="Shakir" last="Ali">Shakir Ali</name><affiliation wicri:level="1"><nlm:aff id="af1-jcp-19-288">Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Prasad, Ram" sort="Prasad, Ram" uniqKey="Prasad R" first="Ram" last="Prasad">Ram Prasad</name><affiliation wicri:level="1"><nlm:aff id="af1-jcp-19-288">Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Mahmood, Amena" sort="Mahmood, Amena" uniqKey="Mahmood A" first="Amena" last="Mahmood">Amena Mahmood</name><affiliation wicri:level="1"><nlm:aff id="af1-jcp-19-288">Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Routray, Indusmita" sort="Routray, Indusmita" uniqKey="Routray I" first="Indusmita" last="Routray">Indusmita Routray</name><affiliation wicri:level="1"><nlm:aff id="af1-jcp-19-288">Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Shinkafi, Tijjani Salihu" sort="Shinkafi, Tijjani Salihu" uniqKey="Shinkafi T" first="Tijjani Salihu" last="Shinkafi">Tijjani Salihu Shinkafi</name><affiliation wicri:level="1"><nlm:aff id="af1-jcp-19-288">Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Sahin, Kazim" sort="Sahin, Kazim" uniqKey="Sahin K" first="Kazim" last="Sahin">Kazim Sahin</name><affiliation wicri:level="1"><nlm:aff id="af2-jcp-19-288">Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig</wicri:regionArea><wicri:noRegion>Elazig</wicri:noRegion></affiliation></author><author><name sortKey="Kucuk, Omer" sort="Kucuk, Omer" uniqKey="Kucuk O" first="Omer" last="Kucuk">Omer Kucuk</name><affiliation wicri:level="2"><nlm:aff id="af3-jcp-19-288">Winship Cancer Institute, Emory University, Atlanta, Georgia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Winship Cancer Institute, Emory University, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25574464</idno><idno type="pmc">4285960</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285960</idno><idno type="RBID">PMC:4285960</idno><idno type="doi">10.15430/JCP.2014.19.4.288</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001008</idno><idno type="wicri:Area/Pmc/Curation">001007</idno><idno type="wicri:Area/Pmc/Checkpoint">000833</idno><idno type="wicri:Area/Ncbi/Merge">001976</idno><idno type="wicri:Area/Ncbi/Curation">001976</idno><idno type="wicri:Area/Ncbi/Checkpoint">001976</idno><idno type="wicri:doubleKey">2288-3649:2014:Ali S:eugenol:rich:fraction</idno><idno type="wicri:Area/Main/Merge">000A97</idno><idno type="wicri:Area/Main/Curation">000A95</idno><idno type="wicri:Area/Main/Exploration">000A95</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Eugenol-rich Fraction of <italic>Syzygium aromaticum</italic> (Clove) Reverses Biochemical and Histopathological Changes in Liver Cirrhosis and Inhibits Hepatic Cell Proliferation</title><author><name sortKey="Ali, Shakir" sort="Ali, Shakir" uniqKey="Ali S" first="Shakir" last="Ali">Shakir Ali</name><affiliation wicri:level="1"><nlm:aff id="af1-jcp-19-288">Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Prasad, Ram" sort="Prasad, Ram" uniqKey="Prasad R" first="Ram" last="Prasad">Ram Prasad</name><affiliation wicri:level="1"><nlm:aff id="af1-jcp-19-288">Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Mahmood, Amena" sort="Mahmood, Amena" uniqKey="Mahmood A" first="Amena" last="Mahmood">Amena Mahmood</name><affiliation wicri:level="1"><nlm:aff id="af1-jcp-19-288">Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Routray, Indusmita" sort="Routray, Indusmita" uniqKey="Routray I" first="Indusmita" last="Routray">Indusmita Routray</name><affiliation wicri:level="1"><nlm:aff id="af1-jcp-19-288">Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Shinkafi, Tijjani Salihu" sort="Shinkafi, Tijjani Salihu" uniqKey="Shinkafi T" first="Tijjani Salihu" last="Shinkafi">Tijjani Salihu Shinkafi</name><affiliation wicri:level="1"><nlm:aff id="af1-jcp-19-288">Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Sahin, Kazim" sort="Sahin, Kazim" uniqKey="Sahin K" first="Kazim" last="Sahin">Kazim Sahin</name><affiliation wicri:level="1"><nlm:aff id="af2-jcp-19-288">Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig</wicri:regionArea><wicri:noRegion>Elazig</wicri:noRegion></affiliation></author><author><name sortKey="Kucuk, Omer" sort="Kucuk, Omer" uniqKey="Kucuk O" first="Omer" last="Kucuk">Omer Kucuk</name><affiliation wicri:level="2"><nlm:aff id="af3-jcp-19-288">Winship Cancer Institute, Emory University, Atlanta, Georgia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Winship Cancer Institute, Emory University, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Cancer Prevention</title><idno type="ISSN">2288-3649</idno><idno type="eISSN">2288-3657</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Dried flower bud of <italic>Syzygium aromaticum</italic> (clove) is rich in eugenol, an antioxidant and antiinflammatory compound that can protect liver against injury. Clove, besides eugenol, also contains other pharmacologically active phytochemicals such as β-sitosterol and ascorbic acid. This study reports the effect of eugenol-rich fraction (ERF) of clove on liver cirrhosis induced by thioacetamide.</p></sec><sec><title>Methods:</title><p>Cirrhosis of the liver, which predisposes to hepatocellular carcinoma, was induced by administering thioacetamide (0.03%) in drinking water for 16 weeks. Cirrhotic animals were divided into two groups; the treated group was administered ERF for 9 weeks, one week after discontinuation of thioacetamide, while the other group received normal saline for a similar duration of time.</p></sec><sec><title>Results:</title><p>The treatment with ERF, as determined by histopathology and through a battery of biochemical markers of hepatic injury, oxidative stress and drug metabolizing enzymes, significantly ameliorated the signs of liver cirrhosis. It lowered the elevated levels of alkaline phosphatase, γ-glutamyl transferase and other biochemical changes in liver cirrhosis. Histopathology of the liver corroborated the effect of ERF with biochemical findings. ERF treatment further inhibited cell proliferation, as demonstrated by reduced [<sup>3</sup>H]-thymidine uptake.</p></sec><sec><title>Conclusions:</title><p>Data provide evidence supporting the protective action of ERF on liver cirrhosis. The study assumes significance because cirrhosis predisposes the liver to cancer, which is characterized by abnormal cell proliferation. ERF in this study is reported to inhibit hepatic cell proliferation and at the same time decrease oxidative stress, which might be the mechanism of protection against liver cirrhosis.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Dutta, D" uniqKey="Dutta D">D Dutta</name></author><author><name sortKey="Devi, Ss" uniqKey="Devi S">SS Devi</name></author><author><name sortKey="Krishnamurthi, K" uniqKey="Krishnamurthi K">K Krishnamurthi</name></author><author><name sortKey="Kumar, K" uniqKey="Kumar K">K Kumar</name></author><author><name sortKey="Vyas, P" uniqKey="Vyas P">P Vyas</name></author><author><name sortKey="Muthal, Pl" uniqKey="Muthal P">PL Muthal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="D Vila Farias, M" uniqKey="D Vila Farias M">M d’Avila Farias</name></author><author><name sortKey="Oliveira, Ps" uniqKey="Oliveira P">PS Oliveira</name></author><author><name sortKey="Dutra, Fs" uniqKey="Dutra F">FS Dutra</name></author><author><name sortKey="Fernandes, Tj" uniqKey="Fernandes T">TJ Fernandes</name></author><author><name sortKey="De Pereira, Cm" uniqKey="De Pereira C">CM de Pereira</name></author><author><name sortKey="De Oliveira, Sq" uniqKey="De Oliveira S">SQ de Oliveira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeong, Kj" uniqKey="Jeong K">KJ Jeong</name></author><author><name sortKey="Kim Do, Y" uniqKey="Kim Do Y">Y Kim do</name></author><author><name sortKey="Quan, Hy" uniqKey="Quan H">HY Quan</name></author><author><name sortKey="Jo, Hk" uniqKey="Jo H">HK Jo</name></author><author><name sortKey="Kim, Gw" uniqKey="Kim G">GW Kim</name></author><author><name sortKey="Chung, Sh" uniqKey="Chung S">SH Chung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yogalakshmi, B" uniqKey="Yogalakshmi B">B Yogalakshmi</name></author><author><name sortKey="Viswanathan, P" uniqKey="Viswanathan P">P Viswanathan</name></author><author><name sortKey="Anuradha, Cv" uniqKey="Anuradha C">CV Anuradha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pourgholami, Mh" uniqKey="Pourgholami M">MH Pourgholami</name></author><author><name sortKey="Kamalinejad, M" uniqKey="Kamalinejad M">M Kamalinejad</name></author><author><name sortKey="Javadi, M" uniqKey="Javadi M">M Javadi</name></author><author><name sortKey="Majzoob, S" uniqKey="Majzoob S">S Majzoob</name></author><author><name sortKey="Sayyah, M" uniqKey="Sayyah M">M Sayyah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, Gq" uniqKey="Zheng G">GQ Zheng</name></author><author><name sortKey="Kenney, Pm" uniqKey="Kenney P">PM Kenney</name></author><author><name sortKey="Lam, Lk" uniqKey="Lam L">LK Lam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Srivastava, Kc" uniqKey="Srivastava K">KC Srivastava</name></author><author><name sortKey="Malhotra, N" uniqKey="Malhotra N">N Malhotra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kurkawa, M" uniqKey="Kurkawa M">M Kurkawa</name></author><author><name sortKey="Hozumi, T" uniqKey="Hozumi T">T Hozumi</name></author><author><name sortKey="Basnet, P" uniqKey="Basnet P">P Basnet</name></author><author><name sortKey="Nakano, M" uniqKey="Nakano M">M Nakano</name></author><author><name sortKey="Kadota, S" uniqKey="Kadota S">S Kadota</name></author><author><name sortKey="Namba, T" uniqKey="Namba T">T Namba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abdel Wahhab, Ma" uniqKey="Abdel Wahhab M">MA Abdel-Wahhab</name></author><author><name sortKey="Aly, Se" uniqKey="Aly S">SE Aly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chaieb, K" uniqKey="Chaieb K">K Chaieb</name></author><author><name sortKey="Hajlaoui, H" uniqKey="Hajlaoui H">H Hajlaoui</name></author><author><name sortKey="Zmantar, T" uniqKey="Zmantar T">T Zmantar</name></author><author><name sortKey="Kahla Nakbi, Ab" uniqKey="Kahla Nakbi A">AB Kahla-Nakbi</name></author><author><name sortKey="Rouabhia, M" uniqKey="Rouabhia M">M Rouabhia</name></author><author><name sortKey="Mahdouani, K" uniqKey="Mahdouani K">K Mahdouani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miyazawa, M" uniqKey="Miyazawa M">M Miyazawa</name></author><author><name sortKey="Hisama, M" uniqKey="Hisama M">M Hisama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Srivastava, Kc" uniqKey="Srivastava K">KC Srivastava</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanaka, T" uniqKey="Tanaka T">T Tanaka</name></author><author><name sortKey="Orii, Y" uniqKey="Orii Y">Y Orii</name></author><author><name sortKey="Nonaka, G" uniqKey="Nonaka G">G Nonaka</name></author><author><name sortKey="Nishioka, I" uniqKey="Nishioka I">I Nishioka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Umehara, K" uniqKey="Umehara K">K Umehara</name></author><author><name sortKey="Takagi, R" uniqKey="Takagi R">R Takagi</name></author><author><name sortKey="Kuroyanagi, M" uniqKey="Kuroyanagi M">M Kuroyanagi</name></author><author><name sortKey="Ueno, A" uniqKey="Ueno A">A Ueno</name></author><author><name sortKey="Taki, T" uniqKey="Taki T">T Taki</name></author><author><name sortKey="Chen, Yj" uniqKey="Chen Y">YJ Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Sh" uniqKey="Park S">SH Park</name></author><author><name sortKey="Sim, Yb" uniqKey="Sim Y">YB Sim</name></author><author><name sortKey="Lee, Jk" uniqKey="Lee J">JK Lee</name></author><author><name sortKey="Kim, Sm" uniqKey="Kim S">SM Kim</name></author><author><name sortKey="Kang, Yj" uniqKey="Kang Y">YJ Kang</name></author><author><name sortKey="Jung, Js" uniqKey="Jung J">JS Jung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prakash, P" uniqKey="Prakash P">P Prakash</name></author><author><name sortKey="Gupta, N" uniqKey="Gupta N">N Gupta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shin, Sh" uniqKey="Shin S">SH Shin</name></author><author><name sortKey="Park, Jh" uniqKey="Park J">JH Park</name></author><author><name sortKey="Kim, Gc" uniqKey="Kim G">GC Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vishteh, A" uniqKey="Vishteh A">A Vishteh</name></author><author><name sortKey="Thomas, I" uniqKey="Thomas I">I Thomas</name></author><author><name sortKey="Imamura, T" uniqKey="Imamura T">T Imamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Okbi, Sy" uniqKey="Al Okbi S">SY Al-Okbi</name></author><author><name sortKey="Mohamed, Da" uniqKey="Mohamed D">DA Mohamed</name></author><author><name sortKey="Hamed, Te" uniqKey="Hamed T">TE Hamed</name></author><author><name sortKey="Edris, Ae" uniqKey="Edris A">AE Edris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagababu, E" uniqKey="Nagababu E">E Nagababu</name></author><author><name sortKey="Sesikeran, B" uniqKey="Sesikeran B">B Sesikeran</name></author><author><name sortKey="Lakshmaiah, N" uniqKey="Lakshmaiah N">N Lakshmaiah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hernandez Gea, V" uniqKey="Hernandez Gea V">V Hernández-Gea</name></author><author><name sortKey="Ghiassi Nejad, Z" uniqKey="Ghiassi Nejad Z">Z Ghiassi-Nejad</name></author><author><name sortKey="Rozenfeld, R" uniqKey="Rozenfeld R">R Rozenfeld</name></author><author><name sortKey="Gordon, R" uniqKey="Gordon R">R Gordon</name></author><author><name sortKey="Fiel, Mi" uniqKey="Fiel M">MI Fiel</name></author><author><name sortKey="Yue, Z" uniqKey="Yue Z">Z Yue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trappoliere, M" uniqKey="Trappoliere M">M Trappoliere</name></author><author><name sortKey="Caligiuri, A" uniqKey="Caligiuri A">A Caligiuri</name></author><author><name sortKey="Schmid, M" uniqKey="Schmid M">M Schmid</name></author><author><name sortKey="Bertolani, C" uniqKey="Bertolani C">C Bertolani</name></author><author><name sortKey="Failli, P" uniqKey="Failli P">P Failli</name></author><author><name sortKey="Vizzutti, F" uniqKey="Vizzutti F">F Vizzutti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ali, S" uniqKey="Ali S">S Ali</name></author><author><name sortKey="Mann, Da" uniqKey="Mann D">DA Mann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chuang, Hy" uniqKey="Chuang H">HY Chuang</name></author><author><name sortKey="Ng, Lt" uniqKey="Ng L">LT Ng</name></author><author><name sortKey="Lin, Lt" uniqKey="Lin L">LT Lin</name></author><author><name sortKey="Chang, Js" uniqKey="Chang J">JS Chang</name></author><author><name sortKey="Chen, Jy" uniqKey="Chen J">JY Chen</name></author><author><name sortKey="Lin, Tc" uniqKey="Lin T">TC Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murakami, Y" uniqKey="Murakami Y">Y Murakami</name></author><author><name sortKey="Shoji, M" uniqKey="Shoji M">M Shoji</name></author><author><name sortKey="Hanazawa, S" uniqKey="Hanazawa S">S Hanazawa</name></author><author><name sortKey="Tanaka, S" uniqKey="Tanaka S">S Tanaka</name></author><author><name sortKey="Fujisawa, S" uniqKey="Fujisawa S">S Fujisawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chaturvedi, Mm" uniqKey="Chaturvedi M">MM Chaturvedi</name></author><author><name sortKey="Kumar, A" uniqKey="Kumar A">A Kumar</name></author><author><name sortKey="Darnay, Bg" uniqKey="Darnay B">BG Darnay</name></author><author><name sortKey="Chainy, Gb" uniqKey="Chainy G">GB Chainy</name></author><author><name sortKey="Agarwal, S" uniqKey="Agarwal S">S Agarwal</name></author><author><name sortKey="Aggarwal, Bb" uniqKey="Aggarwal B">BB Aggarwal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galvez, M" uniqKey="Galvez M">M Gálvez</name></author><author><name sortKey="Martin Cordero, C" uniqKey="Martin Cordero C">C Martín-Cordero</name></author><author><name sortKey="Houghton, Pj" uniqKey="Houghton P">PJ Houghton</name></author><author><name sortKey="Ayuso, Mj" uniqKey="Ayuso M">MJ Ayuso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamaguchi, T" uniqKey="Yamaguchi T">T Yamaguchi</name></author><author><name sortKey="Takamura, H" uniqKey="Takamura H">H Takamura</name></author><author><name sortKey="Matoba, T" uniqKey="Matoba T">T Matoba</name></author><author><name sortKey="Terao, J" uniqKey="Terao J">J Terao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ali, S" uniqKey="Ali S">S Ali</name></author><author><name sortKey="Pawa, S" uniqKey="Pawa S">S Pawa</name></author><author><name sortKey="Naime, M" uniqKey="Naime M">M Naime</name></author><author><name sortKey="Prasad, R" uniqKey="Prasad R">R Prasad</name></author><author><name sortKey="Ahmad, T" uniqKey="Ahmad T">T Ahmad</name></author><author><name sortKey="Farooqui, H" uniqKey="Farooqui H">H Farooqui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kind, Pr" uniqKey="Kind P">PR Kind</name></author><author><name sortKey="King, Ej" uniqKey="King E">EJ King</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Orlowski, M" uniqKey="Orlowski M">M Orlowski</name></author><author><name sortKey="Meister, A" uniqKey="Meister A">A Meister</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kun, E" uniqKey="Kun E">E Kun</name></author><author><name sortKey="Abood, Lg" uniqKey="Abood L">LG Abood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Claiborne, A" uniqKey="Claiborne A">A Claiborne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carlberg, I" uniqKey="Carlberg I">I Carlberg</name></author><author><name sortKey="Mannervick, B" uniqKey="Mannervick B">B Mannervick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohandas, J" uniqKey="Mohandas J">J Mohandas</name></author><author><name sortKey="Marshall, Jj" uniqKey="Marshall J">JJ Marshall</name></author><author><name sortKey="Duggin, Gg" uniqKey="Duggin G">GG Duggin</name></author><author><name sortKey="Horvath, Js" uniqKey="Horvath J">JS Horvath</name></author><author><name sortKey="Tiller, Dj" uniqKey="Tiller D">DJ Tiller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Habig, Wh" uniqKey="Habig W">WH Habig</name></author><author><name sortKey="Pabst, Mj" uniqKey="Pabst M">MJ Pabst</name></author><author><name sortKey="Fleischner, G" uniqKey="Fleischner G">G Fleischner</name></author><author><name sortKey="Gatmaitan, Z" uniqKey="Gatmaitan Z">Z Gatmaitan</name></author><author><name sortKey="Arias, Im" uniqKey="Arias I">IM Arias</name></author><author><name sortKey="Jakoby, Wb" uniqKey="Jakoby W">WB Jakoby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stirpe, F" uniqKey="Stirpe F">F Stirpe</name></author><author><name sortKey="Della Corte, E" uniqKey="Della Corte E">E Della Corte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bernheim, F" uniqKey="Bernheim F">F Bernheim</name></author><author><name sortKey="Bernheim, Ml" uniqKey="Bernheim M">ML Bernheim</name></author><author><name sortKey="Wilbur, Km" uniqKey="Wilbur K">KM Wilbur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jollow, Dj" uniqKey="Jollow D">DJ Jollow</name></author><author><name sortKey="Mitchell, Jr" uniqKey="Mitchell J">JR Mitchell</name></author><author><name sortKey="Zampagtrone, N" uniqKey="Zampagtrone N">N Zampagtrone</name></author><author><name sortKey="Gillette, Jr" uniqKey="Gillette J">JR Gillette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smart, Rc" uniqKey="Smart R">RC Smart</name></author><author><name sortKey="Huang, Mt" uniqKey="Huang M">MT Huang</name></author><author><name sortKey="Conney, Ah" uniqKey="Conney A">AH Conney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giles, Kw" uniqKey="Giles K">KW Giles</name></author><author><name sortKey="Myers, A" uniqKey="Myers A">A Myers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nissen, Nn" uniqKey="Nissen N">NN Nissen</name></author><author><name sortKey="Martin, P" uniqKey="Martin P">P Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zimmermann, T" uniqKey="Zimmermann T">T Zimmermann</name></author><author><name sortKey="Muller, A" uniqKey="Muller A">A Müller</name></author><author><name sortKey="Machnik, G" uniqKey="Machnik G">G Machnik</name></author><author><name sortKey="Franke, H" uniqKey="Franke H">H Franke</name></author><author><name sortKey="Schubert, H" uniqKey="Schubert H">H Schubert</name></author><author><name sortKey="Dargel, R" uniqKey="Dargel R">R Dargel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aris, Mi" uniqKey="Aris M">MI Aris</name></author><author><name sortKey="Boyer, Jl" uniqKey="Boyer J">JL Boyer</name></author><author><name sortKey="Fausto, N" uniqKey="Fausto N">N Fausto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fontana, L" uniqKey="Fontana L">L Fontana</name></author><author><name sortKey="Moreira, E" uniqKey="Moreira E">E Moreira</name></author><author><name sortKey="Torres, Mi" uniqKey="Torres M">MI Torres</name></author><author><name sortKey="Fernandez, Mi" uniqKey="Fernandez M">MI Fernández</name></author><author><name sortKey="Rios, A" uniqKey="Rios A">A Ríos</name></author><author><name sortKey="Sanchez De Medina, F" uniqKey="Sanchez De Medina F">F Sánchez de Medina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ortega, Ma" uniqKey="Ortega M">MA Ortega</name></author><author><name sortKey="Torres, Mi" uniqKey="Torres M">MI Torres</name></author><author><name sortKey="Fernandez, Mi" uniqKey="Fernandez M">MI Fernández</name></author><author><name sortKey="Rios, A" uniqKey="Rios A">A Rios</name></author><author><name sortKey="Sanchez Pozo, A" uniqKey="Sanchez Pozo A">A Sánchez-Pozo</name></author><author><name sortKey="Gil, A" uniqKey="Gil A">A Gil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abd El Motteleb, Dm" uniqKey="Abd El Motteleb D">DM Abd El Motteleb</name></author><author><name sortKey="Selim, Sa" uniqKey="Selim S">SA Selim</name></author><author><name sortKey="Mohamed, Am" uniqKey="Mohamed A">AM Mohamed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ali, S" uniqKey="Ali S">S Ali</name></author><author><name sortKey="Prasad, R" uniqKey="Prasad R">R Prasad</name></author><author><name sortKey="Naime, M" uniqKey="Naime M">M Naime</name></author><author><name sortKey="Zafar, H" uniqKey="Zafar H">H Zafar</name></author><author><name sortKey="Mahmood, A" uniqKey="Mahmood A">A Mahmood</name></author><author><name sortKey="Routray, I" uniqKey="Routray I">I Routray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ali, S" uniqKey="Ali S">S Ali</name></author><author><name sortKey="Diwakar, G" uniqKey="Diwakar G">G Diwakar</name></author><author><name sortKey="Pawa, S" uniqKey="Pawa S">S Pawa</name></author><author><name sortKey="Siddiqui, Mr" uniqKey="Siddiqui M">MR Siddiqui</name></author><author><name sortKey="Abdin, Mz" uniqKey="Abdin M">MZ Abdin</name></author><author><name sortKey="Ahmad, Fj" uniqKey="Ahmad F">FJ Ahmad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagababu, E" uniqKey="Nagababu E">E Nagababu</name></author><author><name sortKey="Rifkind, Jm" uniqKey="Rifkind J">JM Rifkind</name></author><author><name sortKey="Boindala, S" uniqKey="Boindala S">S Boindala</name></author><author><name sortKey="Nakka, L" uniqKey="Nakka L">L Nakka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Sharif, I" uniqKey="Al Sharif I">I Al-Sharif</name></author><author><name sortKey="Remmal, A" uniqKey="Remmal A">A Remmal</name></author><author><name sortKey="Aboussekhra, A" uniqKey="Aboussekhra A">A Aboussekhra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaur, G" uniqKey="Kaur G">G Kaur</name></author><author><name sortKey="Athar, M" uniqKey="Athar M">M Athar</name></author><author><name sortKey="Alam, Ms" uniqKey="Alam M">MS Alam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Said, Mm" uniqKey="Said M">MM Said</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poli, G" uniqKey="Poli G">G Poli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fouad, Aa" uniqKey="Fouad A">AA Fouad</name></author><author><name sortKey="Yacoubi, Mt" uniqKey="Yacoubi M">MT Yacoubi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bruck, R" uniqKey="Bruck R">R Bruck</name></author><author><name sortKey="Shirin, H" uniqKey="Shirin H">H Shirin</name></author><author><name sortKey="Aeed, H" uniqKey="Aeed H">H Aeed</name></author><author><name sortKey="Matas, Z" uniqKey="Matas Z">Z Matas</name></author><author><name sortKey="Hochman, A" uniqKey="Hochman A">A Hochman</name></author><author><name sortKey="Pines, M" uniqKey="Pines M">M Pines</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prasad, R" uniqKey="Prasad R">R Prasad</name></author><author><name sortKey="Naime, M" uniqKey="Naime M">M Naime</name></author><author><name sortKey="Routray, I" uniqKey="Routray I">I Routray</name></author><author><name sortKey="Mahmood, A" uniqKey="Mahmood A">A Mahmood</name></author><author><name sortKey="Khan, F" uniqKey="Khan F">F Khan</name></author><author><name sortKey="Ali, S" uniqKey="Ali S">S Ali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, Eh" uniqKey="Han E">EH Han</name></author><author><name sortKey="Hwang, Yp" uniqKey="Hwang Y">YP Hwang</name></author><author><name sortKey="Jeong, Tc" uniqKey="Jeong T">TC Jeong</name></author><author><name sortKey="Lee, Ss" uniqKey="Lee S">SS Lee</name></author><author><name sortKey="Shin, Jg" uniqKey="Shin J">JG Shin</name></author><author><name sortKey="Jeong, Hg" uniqKey="Jeong H">HG Jeong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamaguchi, M" uniqKey="Yamaguchi M">M Yamaguchi</name></author><author><name sortKey="Tsurusaki, Y" uniqKey="Tsurusaki Y">Y Tsurusaki</name></author><author><name sortKey="Misawa, H" uniqKey="Misawa H">H Misawa</name></author><author><name sortKey="Inagaki, S" uniqKey="Inagaki S">S Inagaki</name></author><author><name sortKey="Ma, Zj" uniqKey="Ma Z">ZJ Ma</name></author><author><name sortKey="Takahashi, H" uniqKey="Takahashi H">H Takahashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vijayakumar, Rs" uniqKey="Vijayakumar R">RS Vijayakumar</name></author><author><name sortKey="Surya, D" uniqKey="Surya D">D Surya</name></author><author><name sortKey="Nalini, N" uniqKey="Nalini N">N Nalini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dibazar, Sp" uniqKey="Dibazar S">SP Dibazar</name></author><author><name sortKey="Fateh, S" uniqKey="Fateh S">S Fateh</name></author><author><name sortKey="Daneshmandi, S" uniqKey="Daneshmandi S">S Daneshmandi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Estevao Silva, Cf" uniqKey="Estevao Silva C">CF Estevão-Silva</name></author><author><name sortKey="Kummer, R" uniqKey="Kummer R">R Kummer</name></author><author><name sortKey="Fachini Queiroz, Fc" uniqKey="Fachini Queiroz F">FC Fachini-Queiroz</name></author><author><name sortKey="Grespan, R" uniqKey="Grespan R">R Grespan</name></author><author><name sortKey="Nogueira De Melo, Ga" uniqKey="Nogueira De Melo G">GA Nogueira de Melo</name></author><author><name sortKey="Baroni, S" uniqKey="Baroni S">S Baroni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saeed, Sa" uniqKey="Saeed S">SA Saeed</name></author><author><name sortKey="Simjee, Ru" uniqKey="Simjee R">RU Simjee</name></author><author><name sortKey="Shamim, G" uniqKey="Shamim G">G Shamim</name></author><author><name sortKey="Gilani, Ah" uniqKey="Gilani A">AH Gilani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galli, A" uniqKey="Galli A">A Galli</name></author><author><name sortKey="Svegliati Baroni, G" uniqKey="Svegliati Baroni G">G Svegliati-Baroni</name></author><author><name sortKey="Ceni, E" uniqKey="Ceni E">E Ceni</name></author><author><name sortKey="Milani, S" uniqKey="Milani S">S Milani</name></author><author><name sortKey="Ridolfi, F" uniqKey="Ridolfi F">F Ridolfi</name></author><author><name sortKey="Salzano, R" uniqKey="Salzano R">R Salzano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jaganathan, Sk" uniqKey="Jaganathan S">SK Jaganathan</name></author><author><name sortKey="Supriyanto, E" uniqKey="Supriyanto E">E Supriyanto</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Inde</li><li>Turquie</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><country name="Inde"><noRegion><name sortKey="Ali, Shakir" sort="Ali, Shakir" uniqKey="Ali S" first="Shakir" last="Ali">Shakir Ali</name></noRegion><name sortKey="Mahmood, Amena" sort="Mahmood, Amena" uniqKey="Mahmood A" first="Amena" last="Mahmood">Amena Mahmood</name><name sortKey="Prasad, Ram" sort="Prasad, Ram" uniqKey="Prasad R" first="Ram" last="Prasad">Ram Prasad</name><name sortKey="Routray, Indusmita" sort="Routray, Indusmita" uniqKey="Routray I" first="Indusmita" last="Routray">Indusmita Routray</name><name sortKey="Shinkafi, Tijjani Salihu" sort="Shinkafi, Tijjani Salihu" uniqKey="Shinkafi T" first="Tijjani Salihu" last="Shinkafi">Tijjani Salihu Shinkafi</name></country><country name="Turquie"><noRegion><name sortKey="Sahin, Kazim" sort="Sahin, Kazim" uniqKey="Sahin K" first="Kazim" last="Sahin">Kazim Sahin</name></noRegion></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Kucuk, Omer" sort="Kucuk, Omer" uniqKey="Kucuk O" first="Omer" last="Kucuk">Omer Kucuk</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/OrangerV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A95 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A95 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Bois
|area= OrangerV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4285960
|texte= Eugenol-rich Fraction of Syzygium aromaticum (Clove) Reverses Biochemical and Histopathological Changes in Liver Cirrhosis and Inhibits Hepatic Cell Proliferation
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25574464" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a OrangerV1
| This area was generated with Dilib version V0.6.25. |  |